Two sample MR report
LGMN_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 2.4849551 | 2.2204242 | 0.3794506 |
| Weighted median | 4 | -0.2101384 | 0.0810155 | 0.0094921 |
| Inverse variance weighted | 4 | -0.2652396 | 0.0612215 | 0.0000147 |
| Simple mode | 4 | -0.2015319 | 0.1067446 | 0.1554639 |
| Weighted mode | 4 | -0.1967588 | 0.0972242 | 0.1361605 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4830042 | 2 | 0.7854472 |
| Inverse variance weighted | 2.0182760 | 3 | 0.5686221 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.8483042 | 0.6846348 | 0.3410063 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.24e-05 | 0 | TRUE | 0.497327 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
