Two sample MR report
LKAAEAR1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 16 | -0.0456957 | 0.0264414 | 0.1059361 |
| Weighted median | 16 | -0.0125152 | 0.0044303 | 0.0047292 |
| Inverse variance weighted | 16 | -0.0091013 | 0.0034433 | 0.0082129 |
| Simple mode | 16 | -0.0129488 | 0.0067994 | 0.0762173 |
| Weighted mode | 16 | -0.0133229 | 0.0061621 | 0.0471829 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.975548 | 14 | 0.9861501 |
| Inverse variance weighted | 6.923995 | 15 | 0.9597246 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0329989 | 0.0236404 | 0.1844981 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010914 | 0 | TRUE | 0.0016562 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
