Two sample MR report
LRRC4_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0011290 | 0.0614954 | 0.9862318 |
| Weighted median | 6 | 0.0389259 | 0.0197887 | 0.0491744 |
| Inverse variance weighted | 6 | 0.0468901 | 0.0161555 | 0.0037029 |
| Simple mode | 6 | 0.0422434 | 0.0284852 | 0.1981841 |
| Weighted mode | 6 | 0.0387774 | 0.0243954 | 0.1728080 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.3778881 | 4 | 0.9842469 |
| Inverse variance weighted | 0.9726815 | 5 | 0.9647390 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0225463 | 0.0292342 | 0.4836011 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001506 | 0 | TRUE | 0.2438358 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
