Two sample MR report
LTBR_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0866056 | 1.9599802 | 0.9718880 |
| Weighted median | 3 | -0.1420139 | 0.0550519 | 0.0098905 |
| Inverse variance weighted | 3 | -0.1415457 | 0.0457851 | 0.0019913 |
| Simple mode | 3 | -0.1438077 | 0.0611364 | 0.1429684 |
| Weighted mode | 3 | -0.1433231 | 0.0618603 | 0.1464464 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0000061 | 1 | 0.9980354 |
| Inverse variance weighted | 0.0135636 | 2 | 0.9932412 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1057068 | 0.9078485 | 0.9262064 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.69e-05 | 0 | TRUE | 0.6247117 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
