Two sample MR report
LY86_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0240763 | 0.0419667 | 0.5968865 |
| Weighted median | 6 | -0.0366402 | 0.0100374 | 0.0002619 |
| Inverse variance weighted | 6 | -0.0391840 | 0.0081964 | 0.0000017 |
| Simple mode | 6 | -0.0369732 | 0.0128434 | 0.0346383 |
| Weighted mode | 6 | -0.0364846 | 0.0128655 | 0.0364239 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2935301 | 4 | 0.9902280 |
| Inverse variance weighted | 0.4282659 | 5 | 0.9945152 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0104149 | 0.0283736 | 0.7321659 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003384 | 0 | TRUE | 0.0816795 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
