Two sample MR report
LY86_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0015343 | 0.0561017 | 0.9794924 |
| Weighted median | 6 | -0.0485629 | 0.0133821 | 0.0002846 |
| Inverse variance weighted | 6 | -0.0472301 | 0.0110154 | 0.0000181 |
| Simple mode | 6 | -0.0492613 | 0.0179358 | 0.0404761 |
| Weighted mode | 6 | -0.0477110 | 0.0169459 | 0.0373067 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 3.502923 | 4 | 0.4774340 |
| Inverse variance weighted | 4.192965 | 5 | 0.5219815 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0317363 | 0.0382048 | 0.4528562 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003384 | 0 | TRUE | 0.0821442 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
