Two sample MR report
LY86_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.2717829 | 0.1087933 | 0.0668980 |
| Weighted median | 6 | -0.0837893 | 0.0252161 | 0.0008910 |
| Inverse variance weighted | 6 | -0.0704489 | 0.0211751 | 0.0008780 |
| Simple mode | 6 | -0.0868053 | 0.0341815 | 0.0519231 |
| Weighted mode | 6 | -0.0852666 | 0.0307518 | 0.0392380 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.8765349 | 4 | 0.9279029 |
| Inverse variance weighted | 4.4361450 | 5 | 0.4884722 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1381741 | 0.0732361 | 0.1322546 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0003384 | 0 | TRUE | 0.0809269 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
