Two sample MR report
MACROD2_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0382619 | 0.0300957 | 0.2725042 |
| Weighted median | 6 | -0.0312143 | 0.0095028 | 0.0010207 |
| Inverse variance weighted | 6 | -0.0288579 | 0.0076884 | 0.0001744 |
| Simple mode | 6 | -0.0312478 | 0.0134939 | 0.0684190 |
| Weighted mode | 6 | -0.0312478 | 0.0117723 | 0.0451892 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.626154 | 4 | 0.8040840 |
| Inverse variance weighted | 1.730609 | 5 | 0.8850212 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0073645 | 0.0227866 | 0.7627373 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000144 | 0 | TRUE | 0.2558079 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
