Two sample MR report
MACROD2_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | 0.0245191 | 0.0540582 | 0.6736572 |
| Weighted median | 6 | -0.0226133 | 0.0180130 | 0.2093391 |
| Inverse variance weighted | 6 | -0.0306093 | 0.0143858 | 0.0333581 |
| Simple mode | 6 | -0.0187845 | 0.0268695 | 0.5156649 |
| Weighted mode | 6 | -0.0207590 | 0.0215644 | 0.3799340 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4786984 | 4 | 0.9755413 |
| Inverse variance weighted | 1.5979445 | 5 | 0.9014978 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0432821 | 0.0409115 | 0.3497389 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000144 | 0 | TRUE | 0.2539476 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
