Two sample MR report
MARVELD1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 32 | -0.0065547 | 0.0289786 | 0.8225867 |
| Weighted median | 32 | 0.0063510 | 0.0038657 | 0.1003999 |
| Inverse variance weighted | 32 | 0.0056583 | 0.0028355 | 0.0459864 |
| Simple mode | 32 | 0.0068631 | 0.0072100 | 0.3485187 |
| Weighted mode | 32 | 0.0068631 | 0.0078550 | 0.3889849 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 15.48761 | 30 | 0.9866786 |
| Inverse variance weighted | 15.66694 | 31 | 0.9899378 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0104837 | 0.0247561 | 0.6749655 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0006463 | 0 | TRUE | 0.0155878 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
