Two sample MR report
METTL9_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | 0.0063206 | 0.0481668 | 0.9039041 |
| Weighted median | 5 | 0.0164376 | 0.0103352 | 0.1117334 |
| Inverse variance weighted | 5 | 0.0201974 | 0.0087089 | 0.0203858 |
| Simple mode | 5 | 0.0162358 | 0.0129887 | 0.2794443 |
| Weighted mode | 5 | 0.0160655 | 0.0112610 | 0.2268406 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.7986009 | 3 | 0.8498017 |
| Inverse variance weighted | 0.8844070 | 4 | 0.9267871 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0098798 | 0.033728 | 0.788671 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002229 | 0 | TRUE | 0.1556936 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
