Two sample MR report
MKNK1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0566209 | 0.0920967 | 0.5612642 |
| Weighted median | 8 | 0.0152092 | 0.0084081 | 0.0704697 |
| Inverse variance weighted | 8 | 0.0170149 | 0.0070004 | 0.0150754 |
| Simple mode | 8 | 0.0145469 | 0.0122707 | 0.2744979 |
| Weighted mode | 8 | 0.0141830 | 0.0124138 | 0.2908060 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.013726 | 6 | 0.9850866 |
| Inverse variance weighted | 1.199741 | 7 | 0.9909329 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0280667 | 0.0650755 | 0.6813194 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002167 | 0 | TRUE | 0.1615232 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
