Two sample MR report
MKNK1_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0858790 | 0.1531498 | 0.5991637 |
| Weighted median | 7 | 0.0192508 | 0.0116044 | 0.0971310 |
| Inverse variance weighted | 7 | 0.0190491 | 0.0095715 | 0.0465703 |
| Simple mode | 7 | 0.0196435 | 0.0155310 | 0.2528512 |
| Weighted mode | 7 | 0.0202742 | 0.0170167 | 0.2784722 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0633791 | 5 | 0.9999474 |
| Inverse variance weighted | 0.2545443 | 6 | 0.9996876 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0465886 | 0.1065555 | 0.6801878 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000211 | 0 | TRUE | 0.1666398 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
