Two sample MR report
MKNK1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.1268624 | 0.2507584 | 0.6309617 |
| Weighted median | 8 | -0.0525498 | 0.0223396 | 0.0186569 |
| Inverse variance weighted | 8 | -0.0466897 | 0.0184955 | 0.0115903 |
| Simple mode | 8 | -0.0551485 | 0.0330167 | 0.1387823 |
| Weighted mode | 8 | -0.0543125 | 0.0302751 | 0.1159033 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2761136 | 6 | 0.9996044 |
| Inverse variance weighted | 0.7577482 | 7 | 0.9978516 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1226961 | 0.1767957 | 0.5136413 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002167 | 0 | TRUE | 0.1614231 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
