Two sample MR report
MUC16_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0514032 | 0.1354443 | 0.7690828 |
| Weighted median | 3 | 0.0692610 | 0.0195596 | 0.0003986 |
| Inverse variance weighted | 3 | 0.0703319 | 0.0156316 | 0.0000068 |
| Simple mode | 3 | 0.0689319 | 0.0217024 | 0.0864616 |
| Weighted mode | 3 | 0.0687191 | 0.0241949 | 0.1048298 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0094188 | 1 | 0.9226862 |
| Inverse variance weighted | 0.0292133 | 2 | 0.9854995 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0089301 | 0.0634725 | 0.9110162 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.45e-05 | 0 | TRUE | 0.4178731 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
