Two sample MR report
MXRA7_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 5 | -0.0496842 | 0.3421630 | 0.8937551 |
| Weighted median | 5 | -0.0561522 | 0.0226901 | 0.0133330 |
| Inverse variance weighted | 5 | -0.0567957 | 0.0188701 | 0.0026140 |
| Simple mode | 5 | -0.0559318 | 0.0280396 | 0.1168159 |
| Weighted mode | 5 | -0.0559098 | 0.0278695 | 0.1153067 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0073264 | 3 | 0.9998336 |
| Inverse variance weighted | 0.0077597 | 4 | 0.9999925 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0085113 | 0.4088921 | 0.9846999 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.98e-05 | 0 | TRUE | 0.5502597 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
