Two sample MR report
MZT2A_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.2818156 | 0.3292895 | 0.4169870 |
| Weighted median | 10 | 0.1051761 | 0.0277990 | 0.0001547 |
| Inverse variance weighted | 10 | 0.0976458 | 0.0212493 | 0.0000043 |
| Simple mode | 10 | 0.1121018 | 0.0409624 | 0.0229712 |
| Weighted mode | 10 | 0.1093209 | 0.0410237 | 0.0258406 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.373376 | 8 | 0.9673743 |
| Inverse variance weighted | 2.687494 | 9 | 0.9754088 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0961799 | 0.171608 | 0.5905098 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001428 | 0 | TRUE | 0.2597781 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
