Two sample MR report
NDUFS5_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.3318699 | 0.3671929 | 0.5321405 |
| Weighted median | 3 | 0.1364310 | 0.0548654 | 0.0128953 |
| Inverse variance weighted | 3 | 0.1304367 | 0.0457324 | 0.0043421 |
| Simple mode | 3 | 0.1477982 | 0.0668910 | 0.1577474 |
| Weighted mode | 3 | 0.1450724 | 0.0692390 | 0.1711379 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0379951 | 1 | 0.8454529 |
| Inverse variance weighted | 0.3436722 | 2 | 0.8421172 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0924182 | 0.1671577 | 0.6784738 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 6.73e-05 | 0 | TRUE | 0.4374115 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
