Two sample MR report
NQO2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 14 | 0.1586651 | 0.0574353 | 0.0171993 |
| Weighted median | 14 | 0.0294408 | 0.0077133 | 0.0001351 |
| Inverse variance weighted | 14 | 0.0169522 | 0.0070211 | 0.0157584 |
| Simple mode | 14 | 0.0342881 | 0.0133684 | 0.0235218 |
| Weighted mode | 14 | 0.0339668 | 0.0122400 | 0.0157643 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.58823 | 12 | 0.2647306 |
| Inverse variance weighted | 22.06915 | 13 | 0.0542996 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0969921 | 0.0390994 | 0.0289232 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004943 | 0 | TRUE | 0.035264 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
