Two sample MR report
NQO2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | 0.2490982 | 0.1235766 | 0.0649807 |
| Weighted median | 15 | 0.0937769 | 0.0194294 | 0.0000014 |
| Inverse variance weighted | 15 | 0.0824655 | 0.0154360 | 0.0000001 |
| Simple mode | 15 | 0.1011543 | 0.0293319 | 0.0039154 |
| Weighted mode | 15 | 0.1026112 | 0.0283343 | 0.0027777 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.43762 | 13 | 0.3437621 |
| Inverse variance weighted | 16.48707 | 14 | 0.2845425 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1123107 | 0.0826757 | 0.1974284 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005415 | 0 | TRUE | 0.0278426 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
