Two sample MR report
NRGN_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0693395 | 0.1605680 | 0.7079557 |
| Weighted median | 4 | 0.0350021 | 0.0136285 | 0.0102200 |
| Inverse variance weighted | 4 | 0.0385323 | 0.0113479 | 0.0006849 |
| Simple mode | 4 | 0.0355931 | 0.0158792 | 0.1108076 |
| Weighted mode | 4 | 0.0352636 | 0.0144090 | 0.0918968 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4029240 | 2 | 0.8175346 |
| Inverse variance weighted | 0.8565241 | 3 | 0.8359048 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1093958 | 0.1624292 | 0.5700334 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.39e-05 | 0 | TRUE | 0.4160083 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
