Two sample MR report
PARK7_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 22 | 0.0201572 | 0.0285733 | 0.4886622 |
| Weighted median | 22 | -0.0218628 | 0.0099225 | 0.0275695 |
| Inverse variance weighted | 22 | -0.0248396 | 0.0077619 | 0.0013732 |
| Simple mode | 22 | -0.0219537 | 0.0169782 | 0.2100374 |
| Weighted mode | 22 | -0.0211946 | 0.0165654 | 0.2146948 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.059889 | 20 | 0.9999999 |
| Inverse variance weighted | 4.737421 | 21 | 0.9999156 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0179404 | 0.0109639 | 0.1174136 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002927 | 0 | TRUE | 0.1039533 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
