Two sample MR report
PARK7_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 17 | 0.0024827 | 0.1438128 | 0.9864539 |
| Weighted median | 17 | -0.0283641 | 0.0130872 | 0.0302103 |
| Inverse variance weighted | 17 | -0.0211438 | 0.0106627 | 0.0473719 |
| Simple mode | 17 | -0.0294899 | 0.0215497 | 0.1900790 |
| Weighted mode | 17 | -0.0291677 | 0.0200053 | 0.1641901 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.972051 | 15 | 0.9999730 |
| Inverse variance weighted | 1.999190 | 16 | 0.9999898 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0084535 | 0.0513145 | 0.8713483 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002172 | 0 | TRUE | 0.1607542 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
