Two sample MR report
PEX6_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.1218258 | 0.2036126 | 0.5661755 |
| Weighted median | 10 | -0.0266679 | 0.0167761 | 0.1119157 |
| Inverse variance weighted | 10 | -0.0289359 | 0.0132646 | 0.0291505 |
| Simple mode | 10 | -0.0248695 | 0.0216934 | 0.2811901 |
| Weighted mode | 10 | -0.0218513 | 0.0196405 | 0.2947292 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.284741 | 8 | 0.8305628 |
| Inverse variance weighted | 4.835320 | 9 | 0.8484209 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0720315 | 0.0970761 | 0.4792968 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002212 | 0 | TRUE | 0.157563 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
