Two sample MR report
PLA2G16_Macrophages against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.1812806 | 0.5941730 | 0.8114799 |
| Weighted median | 3 | -0.1043483 | 0.0433313 | 0.0160335 |
| Inverse variance weighted | 3 | -0.1057643 | 0.0359500 | 0.0032611 |
| Simple mode | 3 | -0.1096733 | 0.0521921 | 0.1703848 |
| Weighted mode | 3 | -0.0995235 | 0.0505036 | 0.1875606 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0039346 | 1 | 0.9499843 |
| Inverse variance weighted | 0.2381777 | 2 | 0.8877289 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0812647 | 0.1679068 | 0.7130404 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.41e-05 | 0 | TRUE | 0.5308074 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
