Two sample MR report
PLD1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0420583 | 0.1592720 | 0.8047760 |
| Weighted median | 6 | -0.0399783 | 0.0113447 | 0.0004252 |
| Inverse variance weighted | 6 | -0.0388800 | 0.0097572 | 0.0000675 |
| Simple mode | 6 | -0.0430125 | 0.0153362 | 0.0377866 |
| Weighted mode | 6 | -0.0427417 | 0.0155849 | 0.0406706 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.2956524 | 4 | 0.9900931 |
| Inverse variance weighted | 0.2960521 | 5 | 0.9977167 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0021831 | 0.1091939 | 0.9850067 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 5.55e-05 | 0 | TRUE | 0.482073 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
