Two sample MR report
PNPLA6_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0182235 | 0.0220851 | 0.4960414 |
| Weighted median | 4 | -0.0203193 | 0.0112611 | 0.0711710 |
| Inverse variance weighted | 4 | -0.0201174 | 0.0095457 | 0.0350752 |
| Simple mode | 4 | -0.0202616 | 0.0138045 | 0.2384685 |
| Weighted mode | 4 | -0.0201774 | 0.0142717 | 0.2523228 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0051342 | 2 | 0.9974362 |
| Inverse variance weighted | 0.0141770 | 3 | 0.9995530 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0019357 | 0.0203555 | 0.93291 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.75e-05 | 0 | TRUE | 0.6188827 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
