Two sample MR report
PNPLA6_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.1054048 | 0.0576012 | 0.2087558 |
| Weighted median | 4 | -0.0652805 | 0.0289775 | 0.0242718 |
| Inverse variance weighted | 4 | -0.0560614 | 0.0247371 | 0.0234337 |
| Simple mode | 4 | -0.0667110 | 0.0390847 | 0.1863929 |
| Weighted mode | 4 | -0.0665353 | 0.0351396 | 0.1546257 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0205445 | 2 | 0.9897803 |
| Inverse variance weighted | 0.9203215 | 3 | 0.8205212 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0507746 | 0.0535278 | 0.4429616 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 2.75e-05 | 0 | TRUE | 0.6197137 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
