Two sample MR report
POMZP3_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 13 | -0.0755336 | 0.0769876 | 0.3476230 |
| Weighted median | 13 | -0.0310244 | 0.0086034 | 0.0003108 |
| Inverse variance weighted | 13 | -0.0214261 | 0.0072935 | 0.0033064 |
| Simple mode | 13 | -0.0387825 | 0.0142612 | 0.0186274 |
| Weighted mode | 13 | -0.0362819 | 0.0135979 | 0.0204791 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 16.5395 | 11 | 0.1222542 |
| Inverse variance weighted | 17.2892 | 12 | 0.1390385 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0355112 | 0.0502905 | 0.4947962 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002353 | 0 | TRUE | 0.146879 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
