Two sample MR report
PRKAR1B_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0069648 | 0.1682652 | 0.9689673 |
| Weighted median | 6 | 0.0566186 | 0.0252964 | 0.0252077 |
| Inverse variance weighted | 6 | 0.0542968 | 0.0204807 | 0.0080225 |
| Simple mode | 6 | 0.0641039 | 0.0320237 | 0.1017101 |
| Weighted mode | 6 | 0.0639035 | 0.0342346 | 0.1209348 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4426647 | 4 | 0.9788372 |
| Inverse variance weighted | 0.5772105 | 5 | 0.9890229 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0395795 | 0.1079034 | 0.7323447 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.81e-05 | 0 | TRUE | 0.4019563 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
