Two sample MR report
PRUNE2_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 12 | 0.0090601 | 0.0713428 | 0.9014625 |
| Weighted median | 12 | 0.0382918 | 0.0134309 | 0.0043578 |
| Inverse variance weighted | 12 | 0.0328635 | 0.0110798 | 0.0030162 |
| Simple mode | 12 | 0.0471470 | 0.0218790 | 0.0541831 |
| Weighted mode | 12 | 0.0457578 | 0.0229711 | 0.0717840 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.519403 | 10 | 0.9905899 |
| Inverse variance weighted | 2.633475 | 11 | 0.9947377 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0207399 | 0.0614068 | 0.7425376 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.000399 | 0 | TRUE | 0.0574003 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
