Two sample MR report
PTGR1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.2173609 | 0.1653782 | 0.4140617 |
| Weighted median | 3 | 0.0567788 | 0.0196786 | 0.0039103 |
| Inverse variance weighted | 3 | 0.0509653 | 0.0158084 | 0.0012644 |
| Simple mode | 3 | 0.0651233 | 0.0256169 | 0.1261171 |
| Weighted mode | 3 | 0.0651233 | 0.0267566 | 0.1353615 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1063994 | 1 | 0.7442812 |
| Inverse variance weighted | 1.1280764 | 2 | 0.5689071 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.1451062 | 0.1435586 | 0.4965869 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.99e-05 | 0 | TRUE | 0.5534818 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
