Two sample MR report
RAC1_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.1253881 | 0.8775626 | 0.8994787 |
| Weighted median | 4 | 0.1577136 | 0.0567077 | 0.0054164 |
| Inverse variance weighted | 4 | 0.1604327 | 0.0480746 | 0.0008464 |
| Simple mode | 4 | 0.1534281 | 0.0735389 | 0.1282223 |
| Weighted mode | 4 | 0.1523080 | 0.0728018 | 0.1275226 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.1862663 | 2 | 0.9110722 |
| Inverse variance weighted | 0.1878659 | 3 | 0.9795240 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0116526 | 0.2913588 | 0.9717312 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 4.2e-05 | 0 | TRUE | 0.5411717 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
