Two sample MR report
RAD51C_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 20 | -0.0137519 | 0.0780920 | 0.8621830 |
| Weighted median | 20 | -0.0312543 | 0.0068492 | 0.0000050 |
| Inverse variance weighted | 20 | -0.0194729 | 0.0063589 | 0.0021963 |
| Simple mode | 20 | -0.0354172 | 0.0101002 | 0.0023598 |
| Weighted mode | 20 | -0.0354172 | 0.0091625 | 0.0010418 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 34.14750 | 18 | 0.0120775 |
| Inverse variance weighted | 34.15775 | 19 | 0.0176057 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0039506 | 0.053736 | 0.9422045 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002177 | 0 | TRUE | 0.1631703 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
