Two sample MR report
RDX_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.1209292 | 0.1266326 | 0.3834534 |
| Weighted median | 7 | 0.0333468 | 0.0195034 | 0.0873035 |
| Inverse variance weighted | 7 | 0.0287835 | 0.0144591 | 0.0465167 |
| Simple mode | 7 | 0.0412908 | 0.0289911 | 0.2042392 |
| Weighted mode | 7 | 0.0369547 | 0.0299553 | 0.2634610 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 4.150282 | 5 | 0.5279884 |
| Inverse variance weighted | 4.686768 | 6 | 0.5845679 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0610763 | 0.083386 | 0.4967684 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001106 | 0 | TRUE | 0.3179555 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
