Two sample MR report
RNASET2_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 8 | 0.0518771 | 0.2106880 | 0.8137135 |
| Weighted median | 8 | 0.0584829 | 0.0132527 | 0.0000102 |
| Inverse variance weighted | 8 | 0.0581650 | 0.0102344 | 0.0000000 |
| Simple mode | 8 | 0.0593128 | 0.0188073 | 0.0160686 |
| Weighted mode | 8 | 0.0586460 | 0.0180288 | 0.0140008 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 1.454075 | 6 | 0.9624866 |
| Inverse variance weighted | 1.454968 | 7 | 0.9838279 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.002643 | 0.0884535 | 0.9771321 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001392 | 0 | TRUE | 0.2665409 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
