Two sample MR report
RPL13_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.5130193 | 1.4648413 | 0.7404431 |
| Weighted median | 7 | 0.4435994 | 0.1338703 | 0.0009209 |
| Inverse variance weighted | 7 | 0.4552671 | 0.1056639 | 0.0000164 |
| Simple mode | 7 | 0.4399193 | 0.1911488 | 0.0609792 |
| Weighted mode | 7 | 0.4399193 | 0.1971018 | 0.0670867 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.4949783 | 5 | 0.9923060 |
| Inverse variance weighted | 0.4965408 | 6 | 0.9978803 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0104694 | 0.2648573 | 0.9699988 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001299 | 0 | TRUE | 0.2815324 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
