Two sample MR report
RPS26_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 21 | -0.0476651 | 0.0337321 | 0.1738142 |
| Weighted median | 21 | -0.0736058 | 0.0094962 | 0.0000000 |
| Inverse variance weighted | 21 | -0.0715624 | 0.0064741 | 0.0000000 |
| Simple mode | 21 | -0.0862106 | 0.0195422 | 0.0002689 |
| Weighted mode | 21 | -0.0826276 | 0.0159226 | 0.0000445 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 17.37357 | 19 | 0.5645754 |
| Inverse variance weighted | 17.89466 | 20 | 0.5943477 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0115709 | 0.0160291 | 0.479168 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010062 | 2e-07 | TRUE | 0.0028169 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
