Two sample MR report
RPS26_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 18 | 0.1388615 | 0.1923386 | 0.4807360 |
| Weighted median | 18 | 0.1231803 | 0.0254121 | 0.0000013 |
| Inverse variance weighted | 18 | 0.1133989 | 0.0356715 | 0.0014780 |
| Simple mode | 18 | 0.2149816 | 0.0547986 | 0.0010954 |
| Weighted mode | 18 | 0.1998769 | 0.0407410 | 0.0001334 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 176.9752 | 16 | 0 |
| Inverse variance weighted | 177.1764 | 17 | 0 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0114116 | 0.0846126 | 0.8943977 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0010221 | 1.4e-06 | TRUE | 0.003306 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
