Two sample MR report
RPS26_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 20 | -0.0211312 | 0.0251350 | 0.4115411 |
| Weighted median | 20 | -0.0398427 | 0.0069036 | 0.0000000 |
| Inverse variance weighted | 20 | -0.0514305 | 0.0049006 | 0.0000000 |
| Simple mode | 20 | -0.0717961 | 0.0120156 | 0.0000095 |
| Weighted mode | 20 | -0.0378098 | 0.0089252 | 0.0004468 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 18.11622 | 18 | 0.4480214 |
| Inverse variance weighted | 19.63496 | 19 | 0.4168368 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.019537 | 0.0159042 | 0.2351115 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0028678 | 2e-07 | TRUE | 4e-07 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
