Two sample MR report
RPS26_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 23 | -0.1507880 | 0.0606110 | 0.0213327 |
| Weighted median | 23 | 0.0116277 | 0.0169274 | 0.4921345 |
| Inverse variance weighted | 23 | 0.0244595 | 0.0118300 | 0.0386784 |
| Simple mode | 23 | 0.0109203 | 0.0295062 | 0.7148464 |
| Weighted mode | 23 | 0.0093858 | 0.0272841 | 0.7341105 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 12.52265 | 21 | 0.9244225 |
| Inverse variance weighted | 21.21363 | 22 | 0.5075712 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.11253 | 0.038171 | 0.0076798 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0029561 | 0 | TRUE | 2e-07 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
