Two sample MR report
RRP7A_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 15 | -0.0076848 | 0.0269766 | 0.7802332 |
| Weighted median | 15 | -0.0149007 | 0.0079864 | 0.0620758 |
| Inverse variance weighted | 15 | -0.0131022 | 0.0058842 | 0.0259682 |
| Simple mode | 15 | -0.0149550 | 0.0123533 | 0.2460885 |
| Weighted mode | 15 | -0.0147955 | 0.0121055 | 0.2418064 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 7.093267 | 13 | 0.8972813 |
| Inverse variance weighted | 7.135611 | 14 | 0.9293576 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0040987 | 0.0199185 | 0.840154 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0005551 | 0 | TRUE | 0.0249257 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
