Two sample MR report
S100A13_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | 0.0254438 | 0.3485706 | 0.9484536 |
| Weighted median | 4 | 0.0295336 | 0.0139514 | 0.0342686 |
| Inverse variance weighted | 4 | 0.0310734 | 0.0125658 | 0.0134040 |
| Simple mode | 4 | 0.0253267 | 0.0187653 | 0.2699377 |
| Weighted mode | 4 | 0.0253267 | 0.0191089 | 0.2769385 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.3075061 | 2 | 0.8574837 |
| Inverse variance weighted | 0.3077673 | 3 | 0.9585611 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.002632 | 0.1628628 | 0.9885731 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0001651 | 0 | TRUE | 0.2223268 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
