Two sample MR report
SAA1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 3 | 0.0847533 | 0.3846177 | 0.8619229 |
| Weighted median | 3 | 0.0520640 | 0.0284676 | 0.0674169 |
| Inverse variance weighted | 3 | 0.0559366 | 0.0237617 | 0.0185696 |
| Simple mode | 3 | 0.0488421 | 0.0309108 | 0.2548619 |
| Weighted mode | 3 | 0.0490574 | 0.0361004 | 0.3071317 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.3365835 | 1 | 0.5618080 |
| Inverse variance weighted | 0.3422185 | 2 | 0.8427295 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0092786 | 0.1236049 | 0.9523007 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 3.4e-05 | 0 | TRUE | 0.581237 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
