Two sample MR report
SCPEP1_Epithelial against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.0120252 | 0.0344221 | 0.7410611 |
| Weighted median | 7 | -0.0311417 | 0.0112974 | 0.0058416 |
| Inverse variance weighted | 7 | -0.0266131 | 0.0088359 | 0.0025960 |
| Simple mode | 7 | -0.0310929 | 0.0176917 | 0.1293439 |
| Weighted mode | 7 | -0.0323567 | 0.0157626 | 0.0859137 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.950307 | 5 | 0.7076471 |
| Inverse variance weighted | 3.142576 | 6 | 0.7907511 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0094488 | 0.0215487 | 0.6793327 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 9.59e-05 | 0 | TRUE | 0.3538242 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
