Two sample MR report
SECISBP2L_Epithelial against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 6 | -0.0066591 | 0.2816514 | 0.9822699 |
| Weighted median | 6 | -0.0829837 | 0.0374509 | 0.0267051 |
| Inverse variance weighted | 6 | -0.0730588 | 0.0300491 | 0.0150440 |
| Simple mode | 6 | -0.0843137 | 0.0489276 | 0.1454544 |
| Weighted mode | 6 | -0.0825403 | 0.0468786 | 0.1385938 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.9574926 | 4 | 0.9161715 |
| Inverse variance weighted | 1.0137113 | 5 | 0.9614523 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0381339 | 0.1608314 | 0.8242239 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.49e-05 | 0 | TRUE | 0.4114008 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
