Two sample MR report
SETD9_Macrophages against finn-b-ASTHMA_ALLERG_EXMORE
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | -0.1815208 | 0.2974949 | 0.5684176 |
| Weighted median | 7 | 0.1008827 | 0.0319068 | 0.0015680 |
| Inverse variance weighted | 7 | 0.0749609 | 0.0274547 | 0.0063267 |
| Simple mode | 7 | 0.1057868 | 0.0438494 | 0.0523952 |
| Weighted mode | 7 | 0.1042201 | 0.0444405 | 0.0574370 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 6.437690 | 5 | 0.2659275 |
| Inverse variance weighted | 7.403275 | 6 | 0.2851561 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.1569262 | 0.1812092 | 0.4260864 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 7.43e-05 | 0 | TRUE | 0.4151648 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
