Two sample MR report
SH3YL1_Epithelial against bbj-a-88
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 11 | -0.1771058 | 0.1220652 | 0.1807487 |
| Weighted median | 11 | -0.0482816 | 0.0131667 | 0.0002455 |
| Inverse variance weighted | 11 | -0.0335581 | 0.0122898 | 0.0063227 |
| Simple mode | 11 | -0.0507032 | 0.0176283 | 0.0164916 |
| Weighted mode | 11 | -0.0484168 | 0.0175433 | 0.0201353 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 14.15510 | 9 | 0.1169141 |
| Inverse variance weighted | 16.35161 | 10 | 0.0899998 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.084525 | 0.0715242 | 0.2675808 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002328 | 0 | TRUE | 0.149435 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
