Two sample MR report
SHTN1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 10 | 0.0263415 | 0.0795393 | 0.7490199 |
| Weighted median | 10 | 0.0601598 | 0.0122945 | 0.0000010 |
| Inverse variance weighted | 10 | 0.0637234 | 0.0089370 | 0.0000000 |
| Simple mode | 10 | 0.0610485 | 0.0183921 | 0.0089505 |
| Weighted mode | 10 | 0.0594929 | 0.0184557 | 0.0104298 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 2.565518 | 8 | 0.9586057 |
| Inverse variance weighted | 2.789224 | 9 | 0.9720685 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.018266 | 0.0386193 | 0.6488663 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002177 | 1e-07 | TRUE | 0.1666662 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
