Two sample MR report
SIRPB1_Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 7 | 0.0080449 | 0.0464124 | 0.8691864 |
| Weighted median | 7 | -0.0213028 | 0.0097007 | 0.0280912 |
| Inverse variance weighted | 7 | -0.0277347 | 0.0073920 | 0.0001754 |
| Simple mode | 7 | -0.0178055 | 0.0160469 | 0.3096545 |
| Weighted mode | 7 | -0.0172935 | 0.0136376 | 0.2517529 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 5.091240 | 5 | 0.4048470 |
| Inverse variance weighted | 5.712427 | 6 | 0.4561625 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| -0.0239245 | 0.0306308 | 0.4701134 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0004572 | 0 | TRUE | 0.0426454 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
